Study of Combination Therapy in The Treatment of Recurrent Breast Cancer

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Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer.

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Breast cancer can begin in different parts of the breast. A breast is made up of three main parts: lobules, ducts, and connective tissue. The lobules are the glands that produce milk. The ducts are tubes that carry milk to the nipple. The connective tissue (which consists of fibrous and fatty tissue) surrounds and holds everything together. Most breast cancers begin in the ducts or lobules. Breast cancer can spread outside the breast through blood vessels and lymph vessels. When breast cancer spreads to other parts of the body, it is said to have metastasized.

Kinds of Breast Cancer

The most common kinds of breast cancer are: Invasive ductal carcinoma. The cancer cells grow outside the ducts into other parts of the breast tissue. Invasive cancer cells can also spread, or metastasize, to other parts of the body. Invasive lobular carcinoma. Cancer cells spread from the lobules to the breast tissues that are close by. These invasive cancer cells can also spread to other parts of the body. There are several other less common kinds of breast cancer, such as Paget’s disease, medullary, mucinous, and inflammatory breast cancer. Ductal carcinoma in situ (DCIS) is a breast disease that may lead to breast cancer. The cancer cells are only in the lining of the ducts and have not spread to other tissues in the breast.

Breast cancer is treated in several ways. It depends on the kind of breast cancer and how far it has spread. People with breast cancer often get more than one kind of treatment such as surgery, biological therapy, hormonal therapy, radiation therapy but our clinical trial concern is Chemotherapy which is Using special medicines to shrink or kill the cancer cells. The drugs can be pills you take or medicines given in your veins, or sometimes both. The study purpose is to evaluate the efficacy and safety of Cabozantinib+Lynparzal for the treatment of breast cancer using Chemotherapy.

Based on phase II clinical trial results showing that 250mg/kg Cabozantinib and Lynparzal were safe and effective in the treatment of breast cancer, the phase III the clinical study is to further verify the efficacy and safety of Chemotherapy using Cabozantinib and Lynparzal for Breast cancer

Trial Objectives:

The study primary objective is to evaluate the efficacy and safety of Cabozantinib+Lynparzal for the treatment of breast Cancer compared tousing placebo plus Lynparzal as the control. The evaluation of the therapeutic effect of the chemotherapy will be done by a comparison between the participants that received Cabozantinib and Lynparzal and the participants that received the placebo plus Lynparzal.

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