Review of Anti-angiogenic Therapy in Breast Cancer

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Abstract

Tumors need sustained blood and nutrition supply in their growth and achieved by vascular endothelial growth factor(VEGF) families, so the anti-angiogenic therapy(AAGT), which aims at stopping the VEGF route to inhibit the overexpression of VEGF ligand family, have huge potential in curing tumors. But in breast cancer treatment, this kind of treatment did not show great efficiency and efficacy, that means AAGT is not as good as scientists believed initially. But there still be great potential to improve this therapy by combining to other treatment like chemotherapy or gene-target therapy to inhibit its toxicity and tumor cell resistance.

Introduction

This opinion paper helps to understand the mechanism of anti-angiogenic therapy(AAGT), its promises, and pitfalls surrounding usage of breast cancer, discuss the present perspective, and explore future direction of both applications of AAGT and treatment of breast cancer.

Tumor growth needs a sustained purveyance of nutrients including oxygen to maintain the expansive proliferation of tumor cells. Therefore, the tumor could induce the germination of new vessels from the surrounding vascular [fig1]with several types of cytokines and growth factors especially VEGF-A. Plus, VEGF usually over-express in most solid cancers [1].

Plus, several preclinical research shows that inhibition VEGF works in animal models for suppressing tumor growth[2,3]. Therefore, inhibition of sprouting angiogenesis by blocking the VEGF signaling pathway exists in suppressing tumor in human beings. (Fig 2) [1].

Breast cancer is a malignant tumor arising from the cells of the breast, which is the most common cancer among American women. Breast cancer has more than five different types, including Ductal carcinoma in situ, Invasive ductal carcinoma, Invasive lobular carcinoma and some other much less in common ones[4]. In breast cancer, the level of angiogenesis is relevant to survival, that is, high levels of VEGF and other angiogenic factors indicate high-risk disease correlating with a poor prognosis.[5]

Search strategy

I gained all the information from current years’ journal paper in both AAGT and breast cancer treatment. Went through those data, analyzed all information provided in recent journals,

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