Characterization of Gelatin A biopolymer for Drug Delivery

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INTRODUCTION

Drug Delivery has become an interesting in the present day bringing together Material Science Engineering, Mechanical Engineering, Bio-medical Engineering and Pharm-ology together. This method helps to provide an effective way to use a compound to achieve a therapeutic effect in humans and animals. The technique involves modification of drug release profiles, absorption, distribution and elimination for the benefit of improving product efficacy, safety, as well as patient compliance and convenience.

Gelatin is a naturally occurring macromolecular and bio degradable protein that is obtained from skins, tissues and bones of animals. It has high water solubility, non toxicity, high mechanical strength and elasticity in dry state making it a perfect material for drug delivery. There are two kinds of Gelatin. Type A, with isoionic value of 7 to 9, is inferred utilizing solely corrosive pretreatment. Type B, with isoionic value of 4 to 5, is the aftereffect of an antacid pretreatment.[2]

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The usual sources of Gelatin are bovine and pig skins and demineralized bones and hooves. This is a cause for problem for people tend to not consume gelatin based medicines due to religious reasons, mad cow disease and social reasons. To solve this, another source of gelatin was experimented for, extraction of Type B gelatin from fresh water fish L. rohita. In this project we look at its extraction, manufacturing of gelatin and the characteristic properties of the type B gelatin obtained.[1]

PROCESSING

Since there are two sorts of Gelatin, there are two fundamental assembling procedures of Gelatin: Alkaline and corrosive process. The subsequent items can be altogether different as far as piece and physical properties.[4]

Acid handled collagen is absorbed weaken corrosive nature of the acid and after that extricated at about pH 4 for gelatin producing. Non-collagenous proteins and mucoproteins of the tissue are isoelectric at this pH and are consequently not so much solvent but rather more promptly coagulated under the extraction conditions. Contaminants which are expelled along these lines rely upon the quality and birthplace of the raw material and the reproducibility of the producers process.[4]

When managing the basic procedure, the pretreatment of the collagen requires a drawn out absorbing the soluble arrangements (by and large, immersed lime-water). A decent measure of the pollutions (proteins and mucosubstances) are dissolvable at the oppressed pH and are separated. Gelatins from soluble base process will in general be cleaner than corrosive created gelatin, yet this variety might be because of the assembling process.[4]

Moreover to the challenges referenced beforehand, the produce of gelatin is liable to more confusions. For instance the aggregate number of carboxyl gatherings accessible for ionization relies on the extraction technique. Distinctive gelatins can have diverse proportions of acidic and essential gathering in this manner distinctive isoelectric focuses.

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